Fungi - Candida albicans - Research News, Data, Publications & Aproaches - ERG11 Mutations - Telomeres - Nuclear Biology & Nuclear Chemistry Aproaches - Nuclear Architecture - Spatial Reprogramming - Non-Elaborate Posts - Post 5

 

 Telomeric and subtelomeric sequences in C. albicans are frequently tethered to the nuclear periphery through interactions involving Sir2p, Rap1p, and Esc1p homologs, establishing a silenced microenvironment akin to heterochromatin (Berman, 2019). ERG11’s subtelomeric position subjects it to this perinuclear silencing, which ensures basal repression under non-stress conditions. However, this anchoring is not immutable. Fluconazole and other azoles induce perturbations in nuclear organization that weaken these tethers, allowing the ERG11 locus to translocate inward toward transcriptionally competent compartments. This motion is mediated by nuclear envelope-associated proteins and possibly by actin-myosin–like dynamics within the nucleoplasm. The result is a structural “awakening” of the locus — an architectural reprogramming that amplifies ERG11’s transcriptional response.

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