Fungi - Candida albicans - Research News, Data, Publications & Aproaches - ERG11 Mutations - Telomeres - Nuclear Biology & Nuclear Chemistry Aproaches - Non-Elaborate Posts - Post 4

 Subtelomeric chromatin is not merely a regulatory backdrop but a mutational crucible. Studies have demonstrated elevated single-nucleotide polymorphism (SNP) frequencies and recombination rates near the ERG11 locus, reflecting the inherent instability of telomere-adjacent sequences. These mutational hotspots foster structural rearrangements and allelic diversification that enhance adaptability against azole drugs. In this context, ERG11 mutations — including Y132F, K143R, and G464S — are not random but are evolutionarily canalized within a genomic niche predisposed to recombination and duplication. Such telomeric mobility contributes to the emergence of multi-resistance phenotypes, wherein nuclear topology orchestrates genomic fluidity at the service of survival.

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Fungi - Candida auris - Non-Elaborate Posts - Post 2

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