Fungi - Candida albicans - Non-Elaborate Posts - Post 7

 

Some statistics say that Candida albicans is the most prevalent cause of fungal disease. Clinical manifestations of infections with Candida species can range from superficial mucosal infections to deep organ involvement usually resulting from hematogenous spread of infection. Despite the significant progress that has been made in the management of patients with such fungal infections, the emergence of antifungal-resistant isolates creates a significant problem with regard to antifungal prophylaxis and empirical treatment strategies.

 Sterols are essential components that function to maintain fluidity in eukaryotic membranes. The azole class of antifungals inhibits ergosterol biosynthesis and allows for the accumulation of toxic methylated sterol precursors. The primary sterol in the fungal cell membrane is ergosterol, and Cyp51 in C. albicans is a critical part of this biosynthetic process.

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