Fungi - Candida albicans - Research News, Data, Publications & Aproaches - ERG11 Mutations - Telomeres - Sub-Telomeric Structures - Chromatin Landscape - Nuclear Biology & Nuclear Chemistry Aproaches - Non-Elaborate Posts - Post 4


Histone chemistry within the ERG11 subtelomeric domain displays remarkable complexity. Methylation at H3K9 and H3K27 residues confers heterochromatic identity, while localized acetylation at H3K14 and H4K16 facilitates transient euchromatic openings during transcriptional bursts (Todd & Selmecki, 2020). These modifications are dynamically regulated by the antagonistic actions of histone deacetylases (Hda1p, Rpd3p) and methyltransferases such as Set1p. Furthermore, non-coding RNAs emerging from adjacent repeats participate in chromatin-loop stabilization and heterochromatin boundary definition. The biochemical interplay of these modifications endows the ERG11 locus with molecular “breathability” — an ability to toggle between compact and open states in response to internal metabolic flux or external antifungal agents.

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Fungi - Candida auris - Non-Elaborate Posts - Post 2

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