Fungi - Candida albicans - Research News, Data, Publications & Aproaches - ERG11 Mutations - Telomeres - Nuclear Biology & Nuclear Chemistry Aproaches - Heme-Dependant Nuclear Chemistry - Non-Elaborate Posts - Post 5

 

 The nuclear chemistry of ERG11 becomes especially vivid under azole stress. Azoles, such as fluconazole and voriconazole, act as competitive inhibitors that coordinate directly to the heme iron via their imidazole or triazole nitrogen atoms. This interaction displaces the oxygen-binding site, forming a stable Fe–N coordination complex that halts demethylation catalysis.

The consequence is not limited to enzymatic inhibition; the altered spin state of the heme iron changes its redox potential, provoking electron leakage and ROS production. These reactive species diffuse through nuclear pores, modifying histone cysteine and lysine residues, which in turn modulate chromatin condensation. Hence, an event of molecular inhibition reverberates through nuclear chemistry, coupling drug binding to epigenetic modulation.

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