Fungi - Candida albicans - Research News, Data, Publications & Aproaches - ERG11 Mutations - Telomeres - Sub-Telomeric Mutation Dynamics - Nuclear Biology & Nuclear Chemistry Aproaches - Nuclear Plasticity - Non-Elaborate Posts - Post 3

The propensity for mutation near ERG11 is also tied to the selective deployment of DNA repair pathways in subtelomeric zones. Unlike euchromatic cores where high-fidelity homologous recombination (HR) predominates, subtelomeric DNA frequently undergoes non-homologous end joining (NHEJ) and microhomology-mediated end joining (MMEJ), both error-prone processes that favor mutagenesis. In C. albicans, telomeric binding proteins such as Rap1p and Sir2p constrain recombination by promoting chromatin compaction, but under stress — including azole exposure — these proteins dissociate, enabling access to the repair machinery. The ensuing repair synthesis not only restores DNA integrity but simultaneously embeds adaptive mutations into ERG11, transforming damage repair into an instrument of evolutionary creativity.

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