Fungi - Candida albicans - Research News, Data, Publications & Aproaches - ERG11 Mutations - Telomeres - Sub-Telomeric Mutation Dynamics - Nuclear Biology & Nuclear Chemistry Aproaches - Nuclear Plasticity - Non-Elaborate Posts - Post 4

 

Frequent recombination near ERG11 produces allelic diversity that parallels classical models of antigenic variation. Anderson et al. (2015) observed that telomere-associated recombination can induce partial gene conversion events involving ERG11 and adjacent open reading frames. These conversions produce hybrid alleles that maintain enzymatic function while modulating azole-binding affinity. The capacity for segmental gene duplication and subsequent divergence enhances C. albicans’ adaptive repertoire, allowing multiple ERG11 variants to coexist within a single nuclear environment. Such genomic mosaics demonstrate that telomeric recombination, though seemingly chaotic, operates under selective pressures that refine biochemical resilience against antifungal compounds.

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