Fungi - Candida albicans - Research News, Data, Publications & Aproaches - ERG11 Mutations - Telomeres - Telomeric Looping - Nuclear Biology & Nuclear Chemistry Aproaches - Nuclear Architecture in the Regulation of ERG11 - Non-Elaborrate Posts - Post 3

 Telomere looping is an exquisite molecular mechanism wherein distal chromosomal ends fold back upon themselves or interact with internal genomic regions to create long-range regulatory contacts. Electron microscopy and Hi-C studies in yeast and fungi reveal that such loops are stabilized by cohesin and condensin complexes, which mediate topological constraints in concert with nucleosome remodeling factors (Brion et al., 2019). In Candida albicans, this looping allows the telomeric chromatin to approach the ERG11 promoter region, bringing repressive histone deacetylases and silencing proteins into proximity. The loop’s configuration — open or closed, compact or relaxed — determines whether ERG11 remains transcriptionally quiescent or poised for activation under antifungal stress.

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