Fungi - Candida albicans - Telomeres Specialized Research Descriptive Posts - Non-Elaborate Posts - Post 1

 

Telomeres, the protective caps at the ends of linear chromosomes, play a crucial role in maintaining genome stability and preventing DNA degradation. In Candida albicans, telomere length and structure are essential for proper chromosome segregation and cell viability. ERG11, encoding lanosterol 14α-demethylase, is a key enzyme in the ergosterol biosynthesis pathway, and mutations in ERG11 are a major mechanism of azole resistance in this fungus.

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