Fungi - Candida albicans - Research News, Data, Publications & Aproaches - ERG11 Mutations - Telomeres - Sub-Telomeric Structures - Chromatin Landscape - Nuclear Biology & Nuclear Chemistry Aproaches - Redox–Chromatin Coupling - Non-Elaborate Posts - Post 9

A striking feature of redox-mediated chromatin modification is its heritability. Once histones undergo oxidation or acetylation changes in response to redox stress, these marks can persist across cell divisions, establishing a “redox memory.” In C. albicans, transient oxidative shocks prime ERG11 for rapid reactivation upon subsequent exposure to antifungal drugs. This phenomenon exemplifies epigenetic hysteresis — the persistence of transcriptional states through chemical imprinting rather than genetic mutation. The nuclear chemistry of redox reactions thereby extends beyond transient adaptation to confer a biochemical memory, ensuring that survival strategies become encoded in the chemical history of chromatin.