Fungi - Candida albicans - Research News, Data, Publications & Aproaches - ERG11 Mutations - Telomeres - Sub-Telomeric Structures - Chromatin Landscape - Nuclear Biology & Nuclear Chemistry Aproaches - Spatial and Chemical Determinants of ERG11 Regulation in Candida albicans - Non-Elaborate Posts - Post 2

 

 The nuclear periphery in fungi is not merely a structural shell; it is a metabolically responsive interface. It anchors telomeres, organizes silent chromatin, and mediates stress-induced repositioning of specific loci. In C. albicans, peripheral domains are enriched in proteins such as Esc1p, Sir2p, and Rap1p, which maintain telomere clustering and impose context-dependent repression. Under azole stress or nutrient limitation, these tethers weaken, and genes like ERG11 transiently migrate toward the interior, acquiring transcriptional competence. Thus, the nuclear periphery behaves as a regulatory rheostat, capable of modulating gene expression by adjusting the geometric relationship between chromatin and lamina

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