Fungi - Candida albicans - Research News, Data, Publications & Aproaches - ERG11 Mutations - Telomeres - Sub-Telomeric Structures - Chromatin Landscape - Nuclear Biology & Nuclear Chemistry Aproaches - The Chemical Ecology of the Nuclear Space: Redox Dynamics, Heme Chemistry, and the Molecular Governance of ERG11 - Non-Elaborate Posts - Post 2


The nuclear space of C. albicans is a redox-sensitive compartment, continuously exposed to intracellular ROS originating from mitochondrial respiration, peroxisomal β-oxidation, and antifungal stress responses. While cytoplasmic redox buffering is dominated by glutathione and thioredoxin systems, the nucleus possesses a distinct, more delicately balanced redox architecture. Redox potential within the nucleus (~–220 mV) is slightly less reducing than in the cytoplasm, an adaptation that maintains histone thiol integrity and DNA repair enzyme activity. This subtle oxidation bias profoundly influences nuclear processes, modulating transcription factors, histone deacetylases, and heme-dependent enzymes such as ERG11. Under oxidative stress, nuclear glutathione oxidation leads to reversible S-glutathionylation of regulatory proteins, creating a biochemical relay between environmental oxygen and transcriptional responsiveness.

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Fungi - Candida auris - Non-Elaborate Posts - Post 2

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