Fungi - Candida albicans - Research News, Data, Publications & Aproaches - ERG11 Mutations - Telomeres - Sub-Telomeric Structures - Nuclear Biology & Nuclear Chemistry Aproaches - The Hidden Geography of Fungal Genomes: The Subtelomeric Context of ERG11 in Candida albicans - Non-Elaborate posts - Post 8

 

 The subtelomeric environment also provides structural flexibility through elevated recombination rates. In C. albicans, genomic rearrangements such as duplications or inversions near ERG11 confer adaptive benefits by generating copy number variation or allelic diversity. These events, facilitated by repetitive elements, have been directly correlated with azole resistance phenotypes (Flowers et al., 2015). Thus, subtelomeric structure becomes an adaptive tool: its intrinsic instability transforms selective pressure into genomic innovation. The architecture of the chromosome end, far from a passive terminus, acts as a biological crucible for the evolution of drug resistance.

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