Fungi - Candida albicans - Research News, Data, Publications & Aproaches - ERG11 Mutations - Telomeres - Sub-Telomeric Structures - Chromatin Landscape - Nuclear Biology & Nuclear Chemistry Aproaches - Three-Dimensional Orchestration of ERG11: Telomeric Geometry and Nuclear Regulation - Non-Elaborate Posts - Post 4


The nuclear lamina in C. albicans acts as both scaffold and sensor, mediating mechanical feedback between chromatin and the nuclear envelope. ERG11’s proximity to the lamina situates it within a biomechanical niche sensitive to nuclear tension and oxidative stress. Under azole treatment, alterations in membrane ergosterol composition propagate mechanical strain across the nuclear envelope, leading to subtle repositioning of lamina-associated chromatin domains. This mechanical signal transduction modifies the local topology of ERG11, promoting its detachment from repressive lamina anchors and transient transcriptional activation. Thus, nuclear mechanics and cellular biophysics converge to dictate gene expression in a manner reminiscent of mechanoresponsive gene systems in higher eukaryotes.

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