Fungi - Candida albicans - Research News, Data, Publications & Aproaches - ERG11 Mutations - Telomeres - Sub-Telomeric Structures - Chromatin Landscape - Nuclear Biology & Nuclear Chemistry Aproaches - Redox–Chromatin Coupling - Non-Elaborate Posts - Post 8


The nucleus, though often considered metabolically passive, hosts enzymes of glycolysis, the TCA cycle, and oxidative phosphorylation intermediates. This localized metabolism generates cofactors — NAD⁺, FAD, and acetyl-CoA — that directly influence chromatin-modifying enzymes. During antifungal stress, mitochondrial retrograde signaling elevates nuclear NADH levels, altering redox-dependent transcription. ERG11 thus resides in a nucleus that mirrors the cell’s energetic state: when oxidative phosphorylation falters, chromatin loosens, ERG11 expression rises, and ergosterol biosynthesis compensates for membrane stress. Energy metabolism and nuclear chemistry operate as twin axes of fungal adaptation.

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