Fungi - Candida albicans - Research News, Data, Publications & Aproaches - ERG11 Mutations - Telomeres - Sub-Telomeric Structures - Nuclear Biology & Nuclear Chemistry Aproaches - The Hidden Geography of Fungal Genomes: The Subtelomeric Context of ERG11 in Candida albicans - Non-Elaborate posts - Post 5

 The three-dimensional structure of the fungal nucleus transforms linear genetic information into a regulated, spatially determined transcriptome. Chromosomes fold into topologically associating domains (TADs), bringing distant loci into functional proximity. In this context, ERG11’s subtelomeric location situates it within a chromatin territory influenced by the telomeric clustering phenomenon. These clusters act as regulatory condensates — nuclear substructures that accumulate silencing proteins, such as Sir2p and Rap1p, and histone deacetylases that modulate transcriptional accessibility. Under normal physiological conditions, ERG11 may thus be maintained in a semi-silenced state, its transcription restrained yet poised for activation when ergosterol synthesis is challenged by azole drugs.

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