Fungi - Candida albicans - Research News, Data, Publications & Aproaches - ERG11 Mutations - Telomeres - Epigenetic Modulation and Histone Chemistry of the ERG11 Locus - Nuclear Biology & Nuclear Chemistry Aproaches - Non-Elaborate Posts - Post 4

 

 While acetylation acts as a short-term switch, histone methylation provides a longer-lasting imprint on the ERG11 transcriptional state. The methylation of histone H3 lysine 4 (H3K4me3) typically correlates with active promoters, whereas H3K9me3 and H3K27me3 mark repressed, heterochromatic regions (Brion et al., 2019). In the telomeric region encompassing ERG11, a heterogeneous landscape of methylation marks creates what has been termed a “bivalent chromatin state”—a poised configuration ready to activate or silence transcription as needed. This bivalency allows C. albicans to respond rapidly to antifungal challenges while maintaining nuclear stability, an epigenetic duality that underlies its adaptive success.

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