Fungi - Candida albicans - Research News, Data, Publications & Aproaches - ERG11 Mutations - Telomeres - Epigenetic Modulation and Histone Chemistry of the ERG11 Locus - Nuclear Biology & Nuclear Chemistry Aproaches - Non-Elaborate Posts - Post 2

 

 Histone acetylation represents one of the most dynamic and chemically direct mechanisms for regulating ERG11 accessibility. The balance between acetyltransferase and deacetylase activity defines the electrostatic environment surrounding nucleosomal DNA, effectively dictating how transcriptional machinery interfaces with the ERG11 promoter. In C. albicans, enzymes such as Rpd3p and Hda1p serve as key histone deacetylases, catalyzing the removal of acetyl groups from lysine residues on histone H3 and H4 tails (Todd & Selmecki, 2020). This reaction modulates local charge states and compacts chromatin into a more repressive configuration. Conversely, under azole-induced oxidative stress, acetylation increases via transient inhibition of these deacetylases, promoting a euchromatic transition that permits ERG11 transcriptional activation and consequent ergosterol synthesis.

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Fungi - Candida auris - Non-Elaborate Posts - Post 2

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