If an isolate shows elevated fluconazole MIC or has a documented ERG11 resistance allele, clinicians should consider switching to or initiating therapy with an echinocandin for invasive disease and consult infectious-disease specialists for complex cases.
For non-invasive mucosal disease, therapy should be individualized using susceptibility data, with awareness that ERG11 mutations reduce the probability of success with standard fluconazole regimens.

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