If an isolate shows elevated fluconazole MIC or has a documented ERG11
resistance allele, clinicians should consider switching to or initiating
therapy with an echinocandin for invasive disease and consult
infectious-disease specialists for complex cases.
For non-invasive mucosal disease, therapy should be individualized using
susceptibility data, with awareness that ERG11 mutations reduce the
probability of success with standard fluconazole regimens.
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