The detection of ERG11 mutations is therefore actionable: identifying target-site substitutions helps predict cross-resistance to other azoles (voriconazole, itraconazole, posaconazole) and guides selection of non-azole agents.
In some settings, susceptible-dose dependent (SDD) categorization is used: isolates with intermediate MICs may still respond to higher fluconazole doses, but the presence of ERG11 mutations often reduces the likelihood of clinical success even with dose escalation.

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Fungi - Candida auris - Non-Elaborate Posts - Post 2

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