Fungi - Candida albicans - Non-Eaborate Posts - Post 5

 

Pharmaceutics


Drug discovery targets Erg11/CYP51 and alternative fungal enzymes, whilst already pharmaceuticals include fluconazole, voriconazole, posaconazole, isavuconazole. Formulation work focuses on oral and IV delivery and bioavailability. Pharmacokinetics (drug exposure) affects selection for resistance.
Combination therapy and new classes (echinocandins) are developed to bypass ERG11 resistance. Companion diagnostics may guide antifungal choice clinically. Resistance monitoring shapes formulation and dosing strategies.

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