Fungi - Candida albicans - Research News, Data, Publications & Aproaches - ERG11 Mutations - Telomeres - Nuclear Biology & Nuclear Chemistry Aproaches - Non-Elaborate Posts - Post 1

 Candida albicans telomere structure

C. albicans telomeres are composed of tandem repeats of a 23-bp sequence (5′-ACTTCTTGGTGTACGGATGTCTA-3′). The length of telomeres and repeat number can vary between strains and can respond to environmental factors (e.g. growth temperature). Telomerase in C. albicans exists (TERT/TER) and helps maintain telomeric repeats.The chromatin state near telomeres in C. albicans seems to be heterochromatic (repressive) under many conditions, involving a Sir2-like deacetylase regulating hypoacetylation, affecting expression of genes located ~10–15 kb from telomeres.

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