Fungi - Candida albicans - Research News, Data, Publications & Aproaches - ERG11 Mutations - Telomeres - Sub-Telomeric Mutation Dynamics - Nuclear Biology & Nuclear Chemistry Aproaches - Nuclear Plasticity - Non-Elaborate Posts - Post 2

 

 At the molecular level, subtelomeric fragility emerges from both the sequence composition and replication dynamics of chromosomal ends. Telomeric repeats form secondary DNA structures — G-quadruplexes and hairpins — that impede replication fork progression. Stalled forks in the vicinity of ERG11 increase the probability of break-induced replication (BIR) and template switching, thereby introducing sequence divergence. This mechanistic instability translates into a continual reshaping of the ERG11 coding region, allowing small yet significant amino acid substitutions in its lanosterol demethylase domain. These substitutions alter azole–enzyme interactions through subtle changes in hydrogen bonding and π–π stacking geometries, demonstrating how nuclear structural stress propagates into biochemical adaptation.

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Fungi - Candida auris - Non-Elaborate Posts - Post 2

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