Fungi - Candida albicans - Research News, Data, Publications & Aproaches - ERG11 Mutations - Telomeres - Sub-Telomeric Structures - Chromatin Landscape - Nuclear Biology & Nuclear Chemistry Aproaches - Non-Elaborate Posts - Post 7

 Recent studies using chromosome conformation capture (3C) and Hi-C methods have demonstrated that subtelomeric genes in C. albicans participate in long-range chromatin interactions, sometimes looping toward the nuclear interior under stress (Brion et al., 2019). These loops bring ERG11 into proximity with transcription factories — nuclear microdomains rich in RNA polymerase II, transcriptional coactivators, and chromatin remodelers. The transition from a perinuclear repressed state to an intranuclear active state is accompanied by histone eviction and nucleosome sliding, mediated by ATP-dependent remodelers like SWI/SNF. The resulting three-dimensional choreography highlights how nuclear mechanics translate environmental cues into gene regulatory outcomes.

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