Fungi - Candida albicans - Research News, Data, Publications & Aproaches - ERG11 Mutations - Telomeres - Telomeric Looping - Nuclear Biology & Nuclear Chemistry Aproaches - Nuclear Architecture in the Regulation of ERG11 - Non-Elaborrate Posts - Post 8

 

 A remarkable aspect of telomeric looping is its persistence through mitotic cycles — a form of structural epigenetic memory. Once ERG11 has been activated by loop relaxation under azole stress, its chromatin architecture can remain partially open across generations, maintaining a primed transcriptional state. This persistence is mediated by histone inheritance and the re-establishment of specific nuclear contacts post-replication. The outcome is a cellular lineage predisposed to rapid reactivation of ERG11, accelerating adaptive resistance in fluctuating antifungal environments. Thus, looping confers not only immediate regulatory flexibility but also heritable memory of chemical exposure.

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