Fungi - Candida albicans - Research News, Data, Publications & Aproaches - ERG11 Mutations - Telomeres - Sub-Telomeric Mutation Dynamics - Nuclear Biology & Nuclear Chemistry Aproaches - Nuclear Plasticity - Non-Elaborate Posts - Post 1


The subtelomeric environment in Candida albicans represents one of the most dynamically mutable landscapes within the eukaryotic genome, and ERG11, residing in proximity to this region, is deeply shaped by its genomic neighborhood. Unlike central chromosomal loci, subtelomeres exhibit elevated rates of recombination, replication slippage, and microhomology-mediated repair, all of which foster mutational diversity. This heightened instability arises from the inherent structural fragility of telomeric DNA, characterized by repetitive sequences and partially condensed heterochromatin. Within this volatile architecture, ERG11 accumulates single-nucleotide polymorphisms and copy-number variations that underpin azole resistance, effectively transforming the subtelomeric zone into a genetic testing ground for adaptive evolution.

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