Fungi - Candida albicans - Research News, Data, Publications & Aproaches - ERG11 Mutations - Telomeres - Telomeric Looping - Nuclear Biology & Nuclear Chemistry Aproaches - Nuclear Architecture in the Regulation of ERG11 - Non-Elaborrate Posts - Post 5

 

 The exposure of C. albicans to azole antifungals triggers a cascade of structural and transcriptional events that reconfigure nuclear architecture. Under fluconazole pressure, for instance, fluorescence imaging and ChIP-seq analyses indicate that subtelomeric loops encompassing ERG11 become destabilized, transitioning from compacted heterochromatin to a more open, transcriptionally active conformation (Flowers et al., 2015). This reorganization coincides with the relocalization of ERG11 toward the nuclear periphery, an area enriched in transcriptional factories and RNA polymerase II clusters. The loop opening thus represents not only an epigenetic shift but also a topological liberation, aligning chemical signaling with spatial reprogramming.

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