Fungi - Candida albicans - Research News, Data, Publications & Aproaches - ERG11 Mutations - Telomeres - Sub-Telomeric Mutation Dynamics - Nuclear Biology & Nuclear Chemistry Aproaches - Nuclear Plasticity - Non-Elaborate Posts - Post 7

 

 In addition to point mutations, subtelomeric dynamics foster large-scale genomic rearrangements encompassing ERG11. Segmental duplications, tandem amplifications, and extrachromosomal circular DNA (eccDNA) formation have been reported in multiple Candida isolates. These rearrangements increase gene dosage, augmenting lanosterol demethylase expression and mitigating azole inhibition. Notably, eccDNA derived from telomeric loci can replicate autonomously and reintegrate elsewhere in the genome, further disseminating resistance determinants. This structural fluidity redefines the nuclear genome not as a static repository but as a mobile network of chemical functionality, constantly reconfigured by telomere-proximal recombination.

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