Clinical microbiology labs use broth microdilution or automated platforms to report fluconazole MICs and interpretive categories (susceptible, SDD, resistant) that guide therapy; these results are supplemented by targeted sequencing for ERG11 when resistance is suspected. Because ERG11 mutations do not always act alone, labs often report phenotypic resistance (MIC) as the primary actionable item and reserve genotypic annotation (e.g., presence of Y132F) as an explanatory supplement for clinicians.
Comments
Post a Comment