Fungi - Candida albicans - Research News, Data, Publications & Aproaches - ERG11 Mutations - Telomeres - Epigenetic Modulation and Histone Chemistry of the ERG11 Locus - Nuclear Biology & Nuclear Chemistry Aproaches - Non-Elaborate Posts - Post 3

 

 The NAD+-dependent histone deacetylase Sir2p occupies a particularly influential position in subtelomeric gene silencing in Candida albicans. Acting as a metabolic-epigenetic nexus, Sir2p couples the redox state of the nucleus to chromatin configuration by utilizing NAD+ as a cofactor during deacetylation reactions (Berman, 2019). When cellular metabolism tilts toward a reduced NADH/NAD+ ratio—as occurs under antifungal stress—the activity of Sir2p is diminished, loosening chromatin repression at subtelomeric loci, including ERG11. This phenomenon exemplifies a remarkable instance of nuclear chemical sensing, whereby metabolic shifts are directly imprinted onto the chromatin scaffold through cofactor-dependent enzymatic regulation.

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Fungi - Candida auris - Non-Elaborate Posts - Post 2

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