Fungi - Candida albicans - Research News, Data, Publications & Aproaches - ERG11 Mutations - Telomeres - Nuclear Biology & Nuclear Chemistry Aproaches - Non-Elaborate Posts - Post 8

 

 The nuclear chemistry of ERG11 regulation extends into the post-translational modification landscape of histones. Histone acetylation (via Hda1p and Rpd3p) and methylation dynamics dictate the accessibility of the ERG11 promoter, particularly during adaptive responses to antifungal stress. The subtelomeric milieu promotes histone deacetylation and hypoacetylated nucleosome stability, maintaining basal repression. However, oxidative or azole-induced perturbations can alter NAD+/NADH ratios, modulating Sir2p activity and derepressing ERG11. This tight coupling between nuclear redox biochemistry and chromatin marks exemplifies how chemical states within the nucleus govern genomic expression landscapes.

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