Fungi - Candida albicans - Research News, Data, Publications & Aproaches - ERG11 Mutations - Telomeres - Epigenetic Modulation and Histone Chemistry of the ERG11 Locus - Nuclear Biology & Nuclear Chemistry Aproaches - Non-Elaborate Posts - Post 8

 

 Recent transcriptomic analyses have identified noncoding RNAs transcribed from subtelomeric regions adjacent to ERG11, which may participate in epigenetic fine-tuning through RNA–chromatin interactions. These telomeric long noncoding RNAs (lncRNAs) can recruit histone modifiers to specific loci, modulating the deposition of repressive or activating marks (Finkel et al., 2021). Their transcription is often induced by environmental stress, suggesting that RNA-mediated mechanisms contribute to the dynamic reorganization of the ERG11 chromatin domain. In this context, nuclear RNA emerges as both a product and an architect of chromatin states, adding a layer of chemical and structural complexity to ERG11 regulation.

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