Fungi - Candida albicans - Research News, Data, Publications & Aproaches - ERG11 Mutations - Telomeres - Sub-Telomeric Structures - Chromatin Landscape - Nuclear Biology & Nuclear Chemistry Aproaches - Molecular Resilience and Structural Adaptation of ERG11 - Non-Elaborate Posts - Post 4


Azole resistance mutations frequently exert distal allosteric effects on the placement and redox behavior of the heme cofactor. G464S, for instance, perturbs the meander region that stabilizes the heme propionates, subtly shifting the iron atom’s electronic environment. These changes influence the efficiency of electron transfer from NADPH-cytochrome P450 reductase and modulate the stabilization of the reactive iron-oxo species essential for catalysis. Nuclear redox states, shaped by oxidative stress and metabolic flux, amplify these effects. This integration of structural mutation, catalytic chemistry, and nuclear redox environment underscores the multifaceted resilience of Erg11p.

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Fungi - Candida auris - Non-Elaborate Posts - Post 2

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