Fungi - Candida albicans - Research News, Data, Publications & Aproaches - ERG11 Mutations - Telomeres - Sub-Telomeric Structures - Nuclear Biology & Nuclear Chemistry Aproaches - The Hidden Geography of Fungal Genomes: The Subtelomeric Context of ERG11 in Candida albicans - Non-Elaborate posts - Post 9

 Beyond static structure, the subtelomeric zone of ERG11 exhibits dynamic epigenetic behavior. Exposure to azole stress induces chromatin remodeling that persists through successive cell divisions, a phenomenon akin to molecular memory. This “trained” chromatin state allows for more rapid reactivation upon re-exposure to antifungal agents. Combined with nuclear repositioning toward transcriptionally active domains, this mechanism demonstrates how C. albicans integrates past environmental experience into heritable nuclear architecture — a form of adaptive epigenetics that transcends classical mutation-driven evolution.

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