Fungi - Candida albicans - Research News, Data, Publications & Aproaches - ERG11 Mutations - Telomeres - Sub-Telomeric Structures - Chromatin Landscape - Nuclear Biology & Nuclear Chemistry Aproaches - Three-Dimensional Orchestration of ERG11: Telomeric Geometry and Nuclear Regulation - Non-Elaborate Posts - Post 2

 

 Subtelomeric domains in C. albicans are complex landscapes populated by repetitive sequences, transposable elements, and TLO gene clusters that generate transcriptional noise and plasticity. The ERG11 locus, situated within one such territory, is enveloped by heterochromatin-like chromatin marked by hypoacetylated histones and Sir2p-mediated silencing. However, this silencing is not absolute; it is modulatory and reversible. Upon environmental perturbations—such as azole exposure or oxidative stress—the subtelomeric chromatin can undergo partial decompaction, liberating ERG11 from its repressive domain. This responsiveness transforms subtelomeric space into a molecular rheostat, adjusting gene output through structural relaxation rather than DNA mutation.

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