Fungi - Candida albicans - Research News, Data, Publications & Aproaches - ERG11 Mutations - Telomeres - Sub-Telomeric Structures - Nuclear Biology & Nuclear Chemistry Aproaches - Chromatin Chemistry and Epigenetic Modulation - Non-Elabirate Pists - Post 2

 

 At the structural level, ERG11 is embedded within a chromatin environment that is neither fully heterochromatic nor purely euchromatic. It occupies a “bistable” zone where nucleosome density, histone modifications, and DNA accessibility undergo constant modulation. Chromatin immunoprecipitation (ChIP) assays have demonstrated an enrichment of H3K9me3 and H3K27me2 near its promoter region, hallmarks of facultative heterochromatin (Todd & Selmecki, 2020). Yet these repressive marks coexist with transient peaks of H3K14ac and H4K16ac, indicating the presence of transcriptionally permissive intervals. This dual-state chromatin conformation confers regulatory elasticity—a capacity for ERG11 to switch between quiescent and active states as metabolic and pharmacological conditions dictate.

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Fungi - Candida auris - Non-Elaborate Posts - Post 2

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