Fungi - Candida albicans - Research News, Data, Publications & Aproaches - ERG11 Mutations - Telomeres - Sub-Telomeric Structures - Chromatin Landscape - Nuclear Biology & Nuclear Chemistry Aproaches - ERG11 as a Functional and Structural Axis - Non-Elaborste Posts - Post 5

 

 Spatial mapping of the C. albicans nucleus reveals that ERG11 resides in a chromatin corridor near the nuclear envelope, adjacent to regions tethered by telomeric proteins such as Rap1p and Sir2p. These tethers generate microdomains of repressive potential, modulated by metabolic cues. During azole stress, ERG11 relocates slightly inward, closer to transcription factories enriched in RNA polymerase II and acetylated histone H3, thereby transitioning from a semi-repressed to an active state. The movement is not random but chemically orchestrated, with NAD⁺/NADH ratios and heme redox state influencing the physical migration of the gene locus through post-translational modification of tethering proteins

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Fungi - Candida auris - Non-Elaborate Posts - Post 2

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