Fungi - Candida albicans - Research News, Data, Publications & Aproaches - ERG11 Mutations - Telomeres - Sub-Telomeric Structures - Chromatin Landscape - Nuclear Biology & Nuclear Chemistry Aproaches - Mystery of ERG11 within the Nuclear Landscape - Non-Elaborate Posts - Post 4

 

 The nucleus is not chemically uniform; it possesses gradients of redox potential, ionic strength, and molecular crowding that influence enzymatic and regulatory processes. In the vicinity of ERG11, local redox fluctuations modulate transcription factor activity and chromatin accessibility. Because the ERG11 product itself is a heme-dependent monooxygenase, the gene is exquisitely sensitive to intracellular heme homeostasis and iron availability. Under azole stress, reactive oxygen species accumulate, altering Fe³⁺/Fe²⁺ ratios and impacting both transcriptional initiation and mRNA stabilization. This creates a feedback loop where nuclear chemistry and gene output co-evolve, translating physicochemical perturbations into adaptive gene expression.

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Fungi - Candida auris - Non-Elaborate Posts - Post 2

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