Fungi - Candida albicans - Research News, Data, Publications & Aproaches - ERG11 Mutations - Telomeres - Sub-Telomeric Structures - Chromatin Landscape - Nuclear Biology & Nuclear Chemistry Aproaches - ERG11 as a Functional and Structural Axis - Non-Elaborste Posts - Post 2

 

 Subtelomeric regions in fungal genomes, rich in repetitive DNA, transposon remnants, and recombination hotspots, are paradoxically both silenced and evolutionarily hyperactive. ERG11’s placement in such a region defies the conventional logic that essential genes occupy stable, central chromosomal loci. Instead, C. albicans employs a telomeric embedding strategy to permit stochastic modulation of critical resistance determinants without catastrophic loss of function. Here, nucleosomal arrays alternate between repressive and open configurations, orchestrated by chromatin remodelers like Swi/Snf and histone deacetylases. This dynamic heterochromatin permits bursts of ERG11 transcriptional plasticity — a molecular breathing motion that allows survival under azole exposure while maintaining enzymatic competence.

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Fungi - Candida auris - Non-Elaborate Posts - Post 2

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