Fungi - Candida albicans - Research News, Data, Publications & Aproaches - ERG11 Mutations - Telomeres - Sub-Telomeric Structures - Chromatin Landscape - Nuclear Biology & Nuclear Chemistry Aproaches - Spatial and Chemical Determinants of ERG11 Regulation in Candida albicans - Non-Elaborate Posts - Post 5


The nuclear context of ERG11 cannot be interpreted without considering the chemical language of chromatin. Subtelomeric regions are marked by histone modifications such as H3K9me3 and hypoacetylated H4, which define repressive chromatin domains. However, ERG11 transcription correlates with the local activity of histone acetyltransferases (Hat1p, Gcn5p) and the temporary eviction of nucleosomes from its promoter. This modification landscape responds to the NAD⁺/NADH ratio through the Sir2p deacetylase, linking nuclear redox state to epigenetic tone. Spatial proximity to the lamina, therefore, embeds ERG11 in a redox-sensitive chromatin environment, where chemical fluctuations translate directly into transcriptional outcomes

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