Fungi - Candida albicans - Research News, Data, Publications & Aproaches - ERG11 Mutations - Telomeres - Sub-Telomeric Structures - Chromatin Landscape - Nuclear Biology & Nuclear Chemistry Aproaches - ERG11 as a Functional and Structural Axis - Non-Elaborste Posts - Post 6

 

 The chromatin fiber surrounding ERG11 behaves as a molecular elastic network capable of storing and dissipating regulatory tension. Acetylation loosens nucleosomal contacts, increasing the radius of curvature of chromatin loops and thereby exposing promoter elements to transcriptional machinery. Conversely, Sir2p-driven deacetylation compacts the chromatin fiber, reducing transcriptional frequency. The rate constants of these transitions are not arbitrary but chemically governed by intracellular concentrations of NAD⁺, acetyl-CoA, and ATP — metabolites that directly couple energy metabolism to gene expression geometry. Thus, the control of ERG11 is an exercise in nuclear thermodynamics as much as in transcriptional regulation.

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