Fungi - Candida albicans - Research News, Data, Publications & Aproaches - ERG11 Mutations - Telomeres - Sub-Telomeric Structures - Chromatin Landscape - Nuclear Biology & Nuclear Chemistry Aproaches - Redox–Chromatin Coupling - Non-Elaborate Posts - Post 1


In the nucleus of Candida albicans, gene regulation is not a purely informational process but a biochemical symphony mediated by redox chemistry. The ERG11 gene, encoding lanosterol 14α-demethylase, stands at the crossroads of this interaction. While traditionally regarded as a cytoplasmic component of the ergosterol biosynthetic pathway, ERG11’s transcriptional regulation unfolds within a nuclear environment that is chemically active, redox-sensitive, and metabolically integrated. Its promoter region, wrapped in subtelomeric chromatin, responds to oxidative cues through dynamic changes in histone modifications and chromatin architecture. Thus, nuclear redox balance becomes a language through which environmental chemistry writes directly onto the genome.

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Fungi - Candida auris - Non-Elaborate Posts - Post 2

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