Fungi - Candida albicans - Research News, Data, Publications & Aproaches - ERG11 Mutations - Telomeres - Sub-Telomeric Structures - Chromatin Landscape - Nuclear Biology & Nuclear Chemistry Aproaches - ERG11 as a Functional and Structural Axis - Non-Elaborste Posts - Post 7

 

 Adaptive mutations such as Y132F or K143R in ERG11 exemplify how subtelomeric plasticity expresses itself at the atomic level. These substitutions subtly alter the electrostatic environment of the heme pocket, modifying π–π stacking with azole rings and diminishing drug affinity while preserving catalytic throughput. Computational molecular dynamics simulations demonstrate that such changes redistribute electron density within the active site, lowering binding enthalpy by approximately 1.2–1.8 kcal mol⁻¹. The result is a functional enzyme resistant to inhibition yet chemically efficient — a triumph of telomeric mutability sculpting nuclear chemistry into evolutionary advantage.

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Fungi - Candida auris - Non-Elaborate Posts - Post 2

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