Fungi - Candida albicans - Research News, Data, Publications & Aproaches - ERG11 Mutations - Telomeres - Sub-Telomeric Structures - Nuclear Biology & Nuclear Chemistry Aproaches - Chromatin Chemistry and Epigenetic Modulation - Non-Elabirate Pists - Post 5

 

 Beyond histone modifications, ERG11 expression depends critically on the mechanical repositioning of nucleosomes. ATP-dependent remodeling complexes such as SWI/SNF and ISWI reconfigure nucleosome arrays to either reveal or occlude the promoter (Dunkel & Morschhäuser, 2017). During azole exposure, SWI/SNF activity increases, sliding nucleosomes downstream and generating accessible chromatin windows near the transcription start site. This dynamic repositioning is coupled with transient DNA bending and local topological strain, allowing transcription factors like Upc2p and Ndt80p to bind effectively. The spatial choreography of nucleosomes at ERG11 thus acts as an energy-driven molecular ballet, converting chemical en

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Fungi - Candida auris - Non-Elaborate Posts - Post 2

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