Fungi - Candida albicans - Research News, Data, Publications & Aproaches - ERG11 Mutations - Telomeres - Sub-Telomeric Structures - Nuclear Biology & Nuclear Chemistry Aproaches - Telomeric, Architectural, and Chemical Synthesis - Non-Elaborate Pists - Post 4

  Epigenetic modulation of ERG11 is inseparable from nuclear chemistry. Histone acetylation, methylation, and deacetylation depend on cofactor pools including acetyl-CoA and NAD⁺, both of which fluctuate under drug stress or metabolic reprogramming. These fluctuations permit the gene to transition rapidly between repressed and permissive states without requiring permanent mutation. Telomere-associated proteins such as Sir2p integrate redox status into chromatin behavior, forging a direct biochemical link between oxidative stress and ERG11 regulation. Thus, epigenetic phenomena at this locus are not abstract switches but chemical reactions embedded in a nuclear metabolic network.

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Fungi - Candida auris - Non-Elaborate Posts - Post 2

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