Fungi - Candida albicans - Research News, Data, Publications & Aproaches - ERG11 Mutations - Telomeres - Sub-Telomeric Structures - Chromatin Landscape - Nuclear Biology & Nuclear Chemistry Aproaches - Spatial and Chemical Determinants of ERG11 Regulation in Candida albicans - Non-Elaborate Posts - Post 3


The subtelomeric domain represents a paradoxical genomic environment — simultaneously a cradle of innovation and a crucible of repression. These regions display high recombination frequencies, repetitive elements, and elevated mutation rates. In most organisms, essential genes are shielded from such volatility; yet ERG11’s localization within this mutable territory implies selective utility. The gene’s product, lanosterol 14α-demethylase, is indispensable, but its regulation must remain flexible under antifungal assault. Subtelomeric residence allows for transcriptional plasticity and rapid allelic diversification, thereby providing a mechanistic foundation for the recurrent emergence of azole resistance mutations.

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Fungi - Candida auris - Non-Elaborate Posts - Post 2

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