Fungi - Candida albicans - Research News, Data, Publications & Aproaches - ERG11 Mutations - Telomeres - Sub-Telomeric Structures - Chromatin Landscape - Nuclear Biology & Nuclear Chemistry Aproaches - Spatial and Chemical Determinants of ERG11 Regulation in Candida albicans - Non-Elaborate Posts - Post 6


The nucleus of C. albicans operates as a feedback-regulated system in which metabolism and spatial structure mutually inform each other. When ergosterol synthesis is inhibited by azoles, the accumulation of sterol intermediates triggers redox imbalance, which in turn alters the activity of chromatin-modifying enzymes. ERG11, located within a redox-responsive chromatin zone, is directly reactivated through this metabolic feedback. Consequently, nuclear architecture is implicated not merely as a scaffold but as a sensor and responder to cellular metabolic flux, demonstrating an exquisite convergence of chemistry and topology in gene control

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