Fungi - Candida albicans - Research News, Data, Publications & Aproaches - ERG11 Mutations - Telomeres - Sub-Telomeric Structures - Nuclear Biology & Nuclear Chemistry Aproaches - The Evolutionary Logic of Telomeric Embedding of ERG11 - Non-Elaborate Posts - Post 7

 Telomeric zones also participate in structural genome plasticity at the chromosomal level. Aneuploidies, telomere truncations, and segmental duplications occur with elevated frequency near chromosome ends. These large-scale modifications have been repeatedly documented in azole-resistant C. albicans isolates, specifically involving chromosome 5 aneuploidies that amplify ERG11 copy number. Gene dosage increase provides immediate physiological benefits when single-copy variants are insufficient to overcome azole inhibition. The subtelomeric architecture thus serves as a springboard not only for point mutations but also for macroscopic genomic rearrangements, enabling multifaceted adaptation through structural and genetic mechanisms.

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