Fungi - Candida albicans - Research News, Data, Publications & Aproaches - ERG11 Mutations - Telomeres - Sub-Telomeric Structures - Chromatin Landscape - Nuclear Biology & Nuclear Chemistry Aproaches - Redox–Chromatin Coupling - Non-Elaborate Posts - Post 6


From a molecular orbital perspective, redox reactions within the nucleus mediate electron transfer across proteins, DNA, and small molecules. Such electron flux subtly alters local dipole moments and ionic distribution, modulating chromatin compaction. For ERG11, the equilibrium between acetylated and deacetylated histones near its promoter depends on these electronic parameters. As NAD⁺-dependent deacetylation consumes electrons, the redox potential of the nuclear milieu shifts, feeding back into the enzymatic kinetics of Sir2p. This cyclical exchange defines an epigenetic equilibrium where gene repression and activation oscillate in synchrony with redox homeostasis — a quantum-chemical underpinning for nuclear plasticity.

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