Fungi - Candida albicans - Research News, Data, Publications & Aproaches - ERG11 Mutations - Telomeres - Sub-Telomeric Structures - Nuclear Biology & Nuclear Chemistry Aproaches - Telomeric, Architectural, and Chemical Synthesis - Non-Elaborate Pists - Post 5

 

 The frequently observed resistance-associated mutations in ERG11 arise not solely from selective pressure but also from its spatial location within a mutationally permissive subtelomeric domain. Peripheral chromosomal regions experience elevated rates of replication slippage, recombination, and chromatin remodeling. These features render the telomeric milieu an evolutionary crucible. The resulting mutations—such as Y132F or K143R—modify the enzyme’s active-site geometry and heme interactions in ways that recalibrate azole-binding energetics. Such structural adaptations arise as natural outcomes of nuclear spatial chemistry, illustrating how the architecture of the genome shapes the trajectory of molecular evolution.

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Fungi - Candida auris - Non-Elaborate Posts - Post 2

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